Hedgehog Antagonist REN Regulates Proliferation and Apoptosis of Developing Granule Cell Progenitors
نویسندگان
چکیده
Beatrice Argenti,1 Rita Gallo,3 Lucia Di Marcotullio,1 Elisabetta Ferretti,1 Maddalena Napolitano,1 Sonia Canterini,2 Enrico De Smaele,1 Azzura Greco,1 Maria Teresa Fiorenza,2 Marella Maroder,1 Isabella Screpanti,1,4 Edoardo Alesse,3 and Alberto Gulino1,5 Departments of 1Experimental Medicine and Pathology and 2Psychology, University La Sapienza, 00161 Rome, Italy, 3Department of Experimental Medicine, University of L’Aquila, 67100 L’Aquila, Italy, 4Pasteur Institute, Cenci Bolognetti Foundation, 00185 Rome, Italy, and 5Neuromed Institute, 86077 Pozzilli, Isernia, Italy
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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
Purkinje cells (PCs) are the projection neurons of the cerebellar cortex. They receive two major types of synaptic input - that from the inferior olive via climbing fibres and that from the granule neurons via parallel fibres. The precursors of granule neurons proliferate at the surface of the developing cerebellumin the external granule layer (EGL), which persists until postnatal day 14 in the...
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